Huperzine A: Is it an Effective Disease-Modifying Drug for Alzheimer’s Disease?
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منابع مشابه
Huperzine A: Is it an Effective Disease-Modifying Drug for Alzheimer’s Disease?
Alzheimer's disease (AD) is a progressive neurodegenerative disorder for which there is no cure. Huperzine A (HupA) is a natural inhibitor of acetylcholinesterase (AChE) derived from the Chinese folk medicine Huperzia serrata (Qian Ceng Ta). It is a licensed anti-AD drug in China and is available as a nutraceutical in the US. A growing body of evidence has demonstrated that HupA has multifacete...
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BACKGROUND Alzheimer's disease (AD) has become a major public health problem around the world due to its increasing prevalence, long duration, caregiver burden, and high financial cost of care. The degeneration of acetylcholine-containing neurons in the basal forebrain has been implicated in the symptoms of AD. Cholinesterase inhibitors may block the degradation of acetylcholine, thus increasin...
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Alzheimer's disease (AD) is the most frequent cause of dementia. Besides cognitive deterioration, patients with AD are prone to seizures - more than 20% of patients diagnosed with AD experience at least one unprovoked seizure and up to 7% have recurrent seizures. Although available antiepileptic drugs (AEDs) may suppress seizures in patients with AD, they may also worsen cognitive dysfunction a...
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As the most common cause of dementia among the elderly results in cognitive and ‎behavioral impairment, Alzheimer’s disease (AD) is characterized with aggregation of senile ‎plaques (Beta-amyloid protein), cortical atrophy and ventricular enlargement. Unfortunately, ‎conventional methods like acetyl cholinesterase inhibitor drugs, are not so effective owing to ‎restrictive...
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ژورنال
عنوان ژورنال: Frontiers in Aging Neuroscience
سال: 2014
ISSN: 1663-4365
DOI: 10.3389/fnagi.2014.00216